LCBI (Laboratory confirmed
Bloodstream infection) must have at least one of the following conditions;
- The patient must have a pathogen defined in at least 1 blood culture and this pathogen should not be responsible for infection on the other side of the body.
- The patient must have at least one of the following symptoms; Tremor or hypotension; And the pathogen should not be associated with infection in another area, or if the pathogen is a common commensal, it should be shown at least ≥ 2 blood cultures and cultures should be obtained from different parts of the body.
MBI-LCBI denilen bir
kavram da, LCBI’nin bir alt grubu olarak ortaya atılmıştır
(MBI: Mukozal bariyer
injuri).
This concept is the
presence of enteric organisms in at least one blood culture from patients with
neutropenia or diarrhea, who are advanced haemopoietic stem cell transplant
patients with advanced Graft Versus Host disease.
Although the most
sensitive finding in catheter-related bloodstream infection (CRBI) is fever,
the specificity is low.
Inflammation and purulence
in the catheter entry site have better specificity, but lower sensitivity.
Other clinical findings;
Hemodynamic instability, altered mental status, catheter dysfunction,
septicemia findings starting with catheter infusion.
Complications due to
bloodstream infections can also be seen; Suppurative thrombophlebitis,
endocarditis, osteomyelitis, metastatic infection etc.
Conditions where no other
source of infection is present, if the S. aureus, coagulase (-) Staphylococci
and Candida species are obtained in blood cultures, the CRBI is mentioned.
Cultures from peripheral
venules have lower false positives than cultures from the catheter. In blood
cultures from both routes, the (-) predictive value is very good.
If there is no possibility
of obtaining peripheral vascular blood culture; It is necessary to take ≥ 2
blood cultures from 2 separate lumens of the multi-lumen catheter.
Diagnostic criteria for
CRBI;
The production of the same
microorganism from two catheter tips and at least 1 peripheral venous culture,
Production of the same
microorganism from at least 2 blood cultures (one from the central lumen of the
catheter, the other from the peripheral vein or the second lumen of the
catheter). This should meet the criteria of quantitative blood cultures or the
criteria of Differential time to Positivity.
If the quantitative
culture from the catheter hub shows a colony count of ≥ 3 folds compared to the
cultures provided from the peripheral veins or the cultures obtained from the
second lumen, CRBI is considered to be in favor.
In semi- quantitative
culture; If both the catheter entry site, the catheter nipple and the
peripheral culture produce> 15 cfu of the same microorganism, this is in
favor of CRBI.
Diferential time to
positivity; If the cultures taken from the catheter start> 120 minutes
before the culture from the peripheral veins, CRBI can be shown with 85%
sensitivity and 91% specificity.
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